Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression. Please visit our Research page for more info. We also use and develop advanced structural biology computing tools, and apply X-ray Crystallography and NMR in our research.
Recent News:
- A policy forum article by Andrew Morin, et al, published in the Computational Biology Issue of Science.
- A grid-enabled web service for low-resolution crystal structure refinement. Read in Acta Cryst.. Published on Feb 14, 2012.
- Molecular Basis for Interaction of let-7 MicroRNAs with Lin28. Read in Cell. Published on Nov 10, 2011.
- A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Read in Nature Chemical Biology. Published on Nov 13, 2011.
- Our OGT structure has been named by the Protein Data Bank as the September 2011 Molecule of the Month! Read the story by David Goodsell.
- Structure of human O-GlcNAc Transferase. Read in Nature. Published on Jan 16, 2011.
- Yunsun Nam receives Charles A. King Trust Postdoctoral Research Fellowship.
- The shape of things to come - Computing workflow developed by our group highlighted by Children's Vector Blog.
- WSMR highlighted by international Science Grid This Week.
- Wide-Search Molecular Replacement Portal developed by Ian Stokes-Rees now available to members of SBGrid.
- p97 homologue from Trichoplusia ni in ADP free conformation - solved by WSMR. Read in PNAS.
Undegraduate students can apply for a summer internship in our laboratory through HSCI, or our internal NSF program.
The laboratory of Structural Biology, headed by Piotr Sliz, is located in the Seeley G Mudd building (first floor) of the Harvard Medical School in Boston. To get in touch, visit the Contact Us page.